I have the same issue on multiple farms. In this example i'll outline this problem for a three tier farm.
SharePoint web server SharePoint Application server (hosts central admin) Sql server
After installation and configuration i have created two web applications (claims based auth with NTLM).
The client connects on the URLs to the web server (1st tier). All is working correctly and they can access the portal and their mysite. The log file keeps reporting that i need to configure the user accounts for the Object Chache. So, i looked up the required
steps and executed these conform mcrosoft guidelines (http://technet.microsoft.com/en-us/library/ff758656.aspx)
All the steps run seccesfully. But when i connect to the URL i now get an access denied (even with the administrator who is site collection administrator)
In the log file i get the following to lines when i connect to the site.
Unknown SPRequest error occurred. More information: 0x80070002
Unknown SPRequest error occurred. More information: 0x80070005
I have exact the same issue on two other farms.
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